Design considerations for miniaturized optical neural probes

Linda Rudmann; Juan S. Ordonez; Thomas Stieglitz

doi:10.1117/12.2209343

9 March 2016 Design considerations for miniaturized optical neural probes

Linda Rudmann, Juan S. Ordonez, Thomas Stieglitz

Proceedings Volume 9690, Clinical and Translational Neurophotonics; Neural Imaging and Sensing; and Optogenetics and Optical Manipulation; 969025 (2016) https://doi.org/10.1117/12.2209343
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

Neural probes are designed to selectively record from or stimulate nerve cells. In optogenetics it is desirable to build miniaturized and long-term stable optical neural probes, in which the light sources can be directly and chronically implanted into the animals to allow free movement and behavior. Because of the size and the beam shape of the available light sources, it is difficult to target single cells as well as spatially localized networks. We therefore investigated design considerations for packages, which encapsulate the light source hermetically and have integrated hemispherical lens structures that enable to focus the light onto the desired region, by optical simulations. Integration of a biconvex lens into the package lid (diameter = 300 μm, material: silicon carbide) increased the averaged absolute irradiance η_A by 298 % compared to a system without a lens and had a spot size of around 120 μm. Solely integrating a plano-convex lens (same diameter and material) results in an η_A of up to 227 %.

Citation Download Citation

Linda Rudmann, Juan S. Ordonez, and Thomas Stieglitz "Design considerations for miniaturized optical neural probes", Proc. SPIE 9690, Clinical and Translational Neurophotonics; Neural Imaging and Sensing; and Optogenetics and Optical Manipulation, 969025 (9 March 2016); https://doi.org/10.1117/12.2209343

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