Depth-dependent displacement sensitivity analysis and the influence of Doppler angle for quantitative assessment of mechanical properties using phase-sensitive spectral domain optical coherence tomography

Gillian Lynch; Hrebesh Subhash; Sergey Alexandrov; Martin Leahy

doi:10.1117/12.2210964

9 March 2016 Depth-dependent displacement sensitivity analysis and the influence of Doppler angle for quantitative assessment of mechanical properties using phase-sensitive spectral domain optical coherence tomography

Gillian Lynch, Hrebesh Subhash, Sergey Alexandrov, Martin Leahy

Author Affiliations +

Proceedings Volume 9710, Optical Elastography and Tissue Biomechanics III; 97100N (2016) https://doi.org/10.1117/12.2210964
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

Optical coherence elastography (OCE) asesses the mechanical properties of samples by applying a mechanical stimulation and detecting the resulting sample displacement using optical coherence tomography (OCT). OCE methods which utilise the phase of the OCT signal offer the potential to detect displacements on the sub-nanometre scale. However, the displacement sensitivity achieveable is directly related to the signal-to-noise ratio and phase stability of the underlying OCT system. Furthermore, the estimation of Doppler angle is imperative in accurately measuring the sample displacement. This work evaluates the contributions of each of these parameters for quantitative assessment of mechanical properties using phase-sensitive spectral domain OCT.

Conference Presentation

Citation Download Citation

Gillian Lynch, Hrebesh Subhash, Sergey Alexandrov, and Martin Leahy "Depth-dependent displacement sensitivity analysis and the influence of Doppler angle for quantitative assessment of mechanical properties using phase-sensitive spectral domain optical coherence tomography", Proc. SPIE 9710, Optical Elastography and Tissue Biomechanics III, 97100N (9 March 2016); https://doi.org/10.1117/12.2210964

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