Sparse temporal sampling for fast time-domain wide-field fluorescence molecular tomography

Ruoyang Yao; Lingling Zhao; Xavier Intes

doi:10.1117/12.2217760

10 March 2016 Sparse temporal sampling for fast time-domain wide-field fluorescence molecular tomography

Ruoyang Yao, Lingling Zhao, Xavier Intes

Proceedings Volume 9701, Multimodal Biomedical Imaging XI; 970116 (2016) https://doi.org/10.1117/12.2217760
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

Fluorescence Molecular Tomography (FMT) is a powerful optical imaging tool for preclinical research. Especially, its implementation with time-domain (TD) techniques allows lifetime multiplexing for simultaneously imaging multiple biomarkers and provides enhanced data sets for improved resolution and quantification compared to continuous wave (CW) and frequency domain (FD) methodologies. When performing time-domain reconstructions, one important aspect is the selection of a temporal sub-data set. Typically, such selection is performed a posteriori after dense temporal sampling during the acquisition. In this work, we investigate the potential to collect a priori sparse data sets for fast experimental acquisition without compromising FMT performances.

Citation Download Citation

Ruoyang Yao, Lingling Zhao, and Xavier Intes "Sparse temporal sampling for fast time-domain wide-field fluorescence molecular tomography", Proc. SPIE 9701, Multimodal Biomedical Imaging XI, 970116 (10 March 2016); https://doi.org/10.1117/12.2217760

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KEYWORDS

Kidney

Luminescence

Tomography

Fluorescence tomography

Sensors

Monte Carlo methods

Optical tomography

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