Magnetic nanoparticles for thermal lysis and application in cancer treatment

Sumana Das; Brahmanandam Javvaji; Sarath Chandra Veerla; D. Roy Mahapatra

doi:10.1117/12.2217931

15 March 2016 Magnetic nanoparticles for thermal lysis and application in cancer treatment

Sumana Das, Brahmanandam Javvaji, Sarath Chandra Veerla, D. Roy Mahapatra

Proceedings Volume 9708, Photons Plus Ultrasound: Imaging and Sensing 2016; 97083C (2016) https://doi.org/10.1117/12.2217931
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

Chemotherapy and radiation-therapy are conventional treatment procedure of cancer. Though radiation therapy is very common practice for cancer treatment, it has limitations including incomplete and non specific destruction. Heating characteristics of magnetic nanoparticle (MNP) is modelled using molecular dynamics simulation setup. This model would give an understanding for the treatment of cancer cell through MNP associated radiation-therapy. In this paper, alternating magnetic field driven heat generation of MNP is studied using classical molecular dynamics. Temperature is measured as an ensemble average of velocity of the atoms. Temperature stabilization is achieved. Under this simulation setting with certain parameters, 45°C temperature was obtained in our simulations. Simulation data would be helpful for experimental analysis to treat cancerous cell in presence of MNP under exposure to radiofrequency. The in vitro thermal characteristics of magnetite nanoparticles using magnetic coil of various frequencies (5, 7.5, 10 and 15 kHz), the saturation temperature was found at 0.5 mg/mL concentration. At frequency 50 kHz the live/dead and MTT assay was performed on magnetite nanoparticles using MC3T3 cells for 10 min duration. Low radio frequency (RF) radiation induced localized heat into the metallic nanoparticles which is clearly understood using the molecular dynamics simulation setup. Heating of nanoparticle trigger the killing of the tumor cells, acts as a local therapy, as it generates less side effects in comparison to other treatments like chemotherapy and radiation therapy.

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Sumana Das, Brahmanandam Javvaji, Sarath Chandra Veerla, and D. Roy Mahapatra "Magnetic nanoparticles for thermal lysis and application in cancer treatment", Proc. SPIE 9708, Photons Plus Ultrasound: Imaging and Sensing 2016, 97083C (15 March 2016); https://doi.org/10.1117/12.2217931

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KEYWORDS

Magnetism

Nanoparticles

Cancer

Oncology

Chemical species

Radiotherapy

Temperature metrology

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