Tethered capsule OCT endomicroscopy: from bench to bedside at the primary care office (Conference Presentation)

Michalina J. Gora; Leigh H. Simmons; Aubrey R. Tiernan; Catriona N. Grant; Amna R. Soomro; Elizabeth S. Walker Corkery; Mireille Rosenberg; Joshua P. Metlay; Guillermo J. Tearney

doi:10.1117/12.2211393

27 April 2016 Tethered capsule OCT endomicroscopy: from bench to bedside at the primary care office (Conference Presentation)

Michalina J. Gora, Leigh H. Simmons, Aubrey R. Tiernan, Catriona N. Grant, Amna R. Soomro, Elizabeth S. Walker Corkery, Mireille Rosenberg, Joshua P. Metlay, Guillermo J. Tearney

Author Affiliations +

Proceedings Volume 9691, Endoscopic Microscopy XI; and Optical Techniques in Pulmonary Medicine III; 969106 (2016) https://doi.org/10.1117/12.2211393
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

We have developed a swallowable tethered capsule OCT endomicroscopy (TCE) device that acquires microscopic images of the entire esophagus in unsedated subjects in a quick and comfortable procedure. To test its capabilities of TCE to become a population-based screening device, we conducted a clinical feasibility study in the primary care office. The swept-source OCT imaging system (1310nm central wavelength, 40kHz A-line rate, 10um axial resolution) together with the tethered capsule catheter (11x25mm capsule attached to a flexible tether) were transferred to the PCP office where unsedated patients scheduled for non-urgent PCP visits swallowed the capsule and microscopic OCT images of the entire esophagus were collected. After the whole length of the esophagus was imaged, the catheter was disinfected for reuse. Twenty subjects were enrolled in the study, including nine female and eleven male. All TCE procedures were performed by a nurse and lasted in average 5:42 ± 1:54 min. High-resolution images of the esophagus were obtained in all seventeen subjects that swallowed the capsule. Our clinical experience in this cohort, subject feedback, image quality, and technological adaptations for efficient utilization in this setting will be presented. The ease and simplicity of the procedure combined with high quality of the images demonstrate the potential for this technology to become a population-based screening device. Technology limitations and future development guided by findings from this initial experience will be discussed with the goal of effectively translating TCE to the outpatient primary care setting.

Conference Presentation

Citation Download Citation

Michalina J. Gora, Leigh H. Simmons, Aubrey R. Tiernan, Catriona N. Grant, Amna R. Soomro, Elizabeth S. Walker Corkery, Mireille Rosenberg, Joshua P. Metlay, and Guillermo J. Tearney "Tethered capsule OCT endomicroscopy: from bench to bedside at the primary care office (Conference Presentation)", Proc. SPIE 9691, Endoscopic Microscopy XI; and Optical Techniques in Pulmonary Medicine III, 969106 (27 April 2016); https://doi.org/10.1117/12.2211393

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
PRESENTATION

WATCH
PRESENTATION SAVE TO MY LIBRARY

GET CITATION

KEYWORDS

Optical coherence tomography

Esophagus

Endomicroscopy

Photomedicine

Image quality

Image resolution

Imaging systems

Show All Keywords

Keywords/Phrases

Search In:

Publication Years