Intraluminal mapping of tissue viscoelastic properties using laser speckle rheology catheter
(Conference Presentation)

Jing Wang; Masaki Hosoda; Diane M. Tshikudi; Seemantini K. Nadkarni

doi:10.1117/12.2213207

27 April 2016 Intraluminal mapping of tissue viscoelastic properties using laser speckle rheology catheter (Conference Presentation)

Jing Wang, Masaki Hosoda, Diane M. Tshikudi, Seemantini K. Nadkarni

Author Affiliations +

Proceedings Volume 9710, Optical Elastography and Tissue Biomechanics III; 97100S (2016) https://doi.org/10.1117/12.2213207
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

A number of disease conditions including coronary atherosclerosis, peripheral artery disease and gastro-intestinal malignancies are associated with alterations in tissue mechanical properties. Laser speckle rheology (LSR) has been demonstrated to provide important information on tissue mechanical properties by analyzing the time scale of temporal speckle intensity fluctuations, which serves as an index of tissue viscoelasticity. In order to measure the mechanical properties of luminal organs in vivo, LSR must be conducted via a miniature endoscope or catheter. Here we demonstrate the capability of an omni-directional LSR catheter to quantify tissue mechanical properties over the entire luminal circumference without the need for rotational motion. Retracting the catheter using a motor-drive assembly enables the reconstruction of cylindrical maps of tissue mechanical properties. The performance of the LSR catheter is tested using a luminal phantom with mechanical moduli that vary in both circumferential and longitudinal directions. 2D cylindrical maps of phantom viscoelastic properties are reconstructed over four quadrants of the coronary circumference simultaneously during catheter pullback. The reconstructed cylindrical maps of the decorrelation time constants easily distinguish the different gel components of the phantom with different viscoelastic moduli. The average values of decorrelation times calculated for each gel component of the phantom show a strong correspondence with the viscoelastic moduli measured via standard mechanical rheometry. These results highlight the capability for cylindrical mapping of tissue viscoelastic properties using LSR in luminal organs using a miniature catheter, thus opening the opportunity for improved diagnosis of several disease conditions.

Conference Presentation

Citation Download Citation

Jing Wang, Masaki Hosoda, Diane M. Tshikudi, and Seemantini K. Nadkarni "Intraluminal mapping of tissue viscoelastic properties using laser speckle rheology catheter (Conference Presentation)", Proc. SPIE 9710, Optical Elastography and Tissue Biomechanics III, 97100S (27 April 2016); https://doi.org/10.1117/12.2213207

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KEYWORDS

Laser tissue interaction

Speckle

Tissues

Arteries

Endoscopes

In vivo imaging

Photomedicine

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