The delayed luminescence spectroscopy as tool to investigate the cytotoxic effect on human cancer cells of drug-loaded nanostructured lipid carrier

R. Grasso; M. Gulino; A. Scordino; F. Musumeci; A. Campisi; R. Bonfanti; C. Carbone; G. Puglisi

doi:10.1117/12.2227514

9 May 2016 The delayed luminescence spectroscopy as tool to investigate the cytotoxic effect on human cancer cells of drug-loaded nanostructured lipid carrier

R. Grasso, M. Gulino, A. Scordino, F. Musumeci, A. Campisi, R. Bonfanti, C. Carbone, G. Puglisi

Author Affiliations +

Proceedings Volume 9887, Biophotonics: Photonic Solutions for Better Health Care V; 988723 (2016) https://doi.org/10.1117/12.2227514
Event: SPIE Photonics Europe, 2016, Brussels, Belgium

Abstract

The first results concerning the possibility to use Delayed Luminescence spectroscopy to evaluate the in vitro induction of cytotoxic effects on human glioblastoma cells of nanostructured lipid carrier and drug-loaded nanostructured lipid carrier are showed in this contribution. We tested the effects of nanostructured lipid carrier, ferulic acid and ferulic acidloaded nanostructured lipid carrier on U-87MG cell line. The study seems to confirm the ability of Delayed Luminescence to be sensible indicator of alterations induced on functionality of the mitochondrial respiratory chain complex I in U-87MG cancer cells when treated with nanostructured lipid carriers.

Citation Download Citation

R. Grasso, M. Gulino, A. Scordino, F. Musumeci, A. Campisi, R. Bonfanti, C. Carbone, and G. Puglisi "The delayed luminescence spectroscopy as tool to investigate the cytotoxic effect on human cancer cells of drug-loaded nanostructured lipid carrier", Proc. SPIE 9887, Biophotonics: Photonic Solutions for Better Health Care V, 988723 (9 May 2016); https://doi.org/10.1117/12.2227514

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