Microwave-to-terahertz dielectric resonators for liquid sensing in microfluidic systems

N. Klein; C. Watts; S. M. Hanham; W. J. Otter; M. M. Ahmad; S. Lucyszyn

doi:10.1117/12.2238545

26 September 2016 Microwave-to-terahertz dielectric resonators for liquid sensing in microfluidic systems

N. Klein, C. Watts, S. M. Hanham, W. J. Otter, M. M. Ahmad, S. Lucyszyn

Proceedings Volume 9934, Terahertz Emitters, Receivers, and Applications VII; 99340F (2016) https://doi.org/10.1117/12.2238545
Event: SPIE Nanoscience + Engineering, 2016, San Diego, California, United States

Abstract

The microwave-to-terahertz frequency range offers unique opportunities for the sensing of liquids based on the degree of molecular orientational and electronic polarization, Debye relaxation due to intermolecular forces between (semi-)polar molecules and collective vibrational modes within complex molecules. Methods for the fast dielectric characterization of (sub-)nanolitre volumes of mostly aqueous liquids and biological cell suspensions are discussed, with emphasis on labon- chip approaches aimed towards single-cell detection and label-free flow cytometry at microwave-to-terahertz frequencies. Among the most promising approaches, photonic crystal defect cavities made from high-resistivity silicon are compared with metallic split-ring resonant systems and high quality factor (Q-factor) whispering gallery-type resonances in dielectric resonators. Applications range from accurate haemoglobin measurements on nanolitre samples to label-free detection of circulating tumor cells.

Conference Presentation

Citation Download Citation

N. Klein, C. Watts, S. M. Hanham, W. J. Otter, M. M. Ahmad, and S. Lucyszyn "Microwave-to-terahertz dielectric resonators for liquid sensing in microfluidic systems", Proc. SPIE 9934, Terahertz Emitters, Receivers, and Applications VII, 99340F (26 September 2016); https://doi.org/10.1117/12.2238545

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