Methods and fiber optics spectrometry system for control of photosensitizer in tissue during photodynamic therapy

Vladimir V. Kholin; Oksana M. Chepurna; Irina O. Shton; Valerii S. Voytsehovich; Olexiy D. Azarov; Sergii V. Pavlov; Nikolai F. Gamaleia; Damian Harasim

doi:10.1117/12.2249259

28 September 2016 Methods and fiber optics spectrometry system for control of photosensitizer in tissue during photodynamic therapy

Vladimir V. Kholin, Oksana M. Chepurna, Irina O. Shton, Valerii S. Voytsehovich, Olexiy D. Azarov, Sergii V. Pavlov, Nikolai F. Gamaleia, Damian Harasim

Author Affiliations +

Proceedings Volume 10031, Photonics Applications in Astronomy, Communications, Industry, and High-Energy Physics Experiments 2016; 1003138 (2016) https://doi.org/10.1117/12.2249259
Event: Photonics Applications in Astronomy, Communications, Industry, and High-Energy Physics Experiments 2016, 2016, Wilga, Poland

Abstract

Photodynamic cancer therapy is used as an alternative or in combination with conventional treatments. PDT involves three key components: a photosensitizer, a light source and tissue oxygen. The combination of these three components leads to the chemical destruction of any tissues which have either selectively taken up the photosensitizer or have been locally exposed to light. In our research we used Charge-coupled device (CCD) spectrometers to measure intensity of the fluorescence signal. Devices allow receiving and processing signal in a CCD structure at a wide range of wavelengths. We have established a system for measuring the fluorescence of tumor tissue. These results are important for determining the dose of laser radiation and optimal time for laser action without damaging healthy tumor.

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Vladimir V. Kholin, Oksana M. Chepurna, Irina O. Shton, Valerii S. Voytsehovich, Olexiy D. Azarov, Sergii V. Pavlov, Nikolai F. Gamaleia, and Damian Harasim "Methods and fiber optics spectrometry system for control of photosensitizer in tissue during photodynamic therapy", Proc. SPIE 10031, Photonics Applications in Astronomy, Communications, Industry, and High-Energy Physics Experiments 2016, 1003138 (28 September 2016); https://doi.org/10.1117/12.2249259

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