The optimum measurement precision evaluation for blood components using near-infrared spectra on 1000-2500 nm

Ziyang Zhang; Di Sun; Tongshuai Han; Chao Guo; Jin Liu

doi:10.1117/12.2245716

31 October 2016 The optimum measurement precision evaluation for blood components using near-infrared spectra on 1000-2500 nm

Ziyang Zhang, Di Sun, Tongshuai Han, Chao Guo, Jin Liu

Author Affiliations +

Proceedings Volume 10024, Optics in Health Care and Biomedical Optics VII; 100242H (2016) https://doi.org/10.1117/12.2245716
Event: SPIE/COS Photonics Asia, 2016, Beijing, China

Abstract

In the non-invasive blood components measurement using near infrared spectroscopy, the useful signals caused by the concentration variation in the interested components, such as glucose, hemoglobin, albumin etc., are relative weak. Then the signals may be greatly disturbed by a lot of noises in various ways. We improved the signals by using the optimum path-length for the used wavelength to get a maximum variation of transmitted light intensity when the concentration of a component varies. And after the path-length optimization for every wavelength in 1000-2500 nm, we present the detection limits for the components, including glucose, hemoglobin and albumin, when measuring them in a tissue phantom. The evaluated detection limits could be the best reachable precision level since it assumed the measurement uses a high signal-to-noise ratio (SNR) signal and the optimum path-length. From the results, available wavelengths in 1000-2500 nm for the three component measurements can be screened by comparing their detection limit values with their measurement limit requirements. For other blood components measurement, the evaluation their detection limits could also be designed using the method proposed in this paper. Moreover, we use an equation to estimate the absorbance at the optimum path-length for every wavelength in 1000-2500 nm caused by the three components. It could be an easy way to realize the evaluation because adjusting the sample cell’s size to the precise path-length value for every wavelength is not necessary. This equation could also be referred to other blood components measurement using the optimum path-length for every used wavelength.

Citation Download Citation

Ziyang Zhang, Di Sun, Tongshuai Han, Chao Guo, and Jin Liu "The optimum measurement precision evaluation for blood components using near-infrared spectra on 1000-2500 nm", Proc. SPIE 10024, Optics in Health Care and Biomedical Optics VII, 100242H (31 October 2016); https://doi.org/10.1117/12.2245716

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available