Photophysical properties of catechol axially substituted tetra-[alpha]-(pentyloxy) titanium (IV) phthalocyanine

Xinxin Yu; Ting Lin; Huafei Lv; Sujuan Pan; Shijun Wu; Di Zeng; Yufeng Jiang; Yuhua Wang; Hongqin Yang; Yide Huang; Yiru Peng

doi:10.1117/12.2246174

31 October 2016 Photophysical properties of catechol axially substituted tetra-α-(pentyloxy) titanium (IV) phthalocyanine

Xinxin Yu, Ting Lin, Huafei Lv, Sujuan Pan, Shijun Wu, Di Zeng, Yufeng Jiang, Yuhua Wang, Hongqin Yang, Yide Huang, Yiru Peng

Author Affiliations +

Proceedings Volume 10024, Optics in Health Care and Biomedical Optics VII; 100243P (2016) https://doi.org/10.1117/12.2246174
Event: SPIE/COS Photonics Asia, 2016, Beijing, China

Abstract

Metal phthalocyanines (MPcs) have been found to be a promising photosensitizers for photodynamic therapy (PDT) of cancers and non-cancer diseases. Nevertheless, phthalocyanines are substantially limited in clinical applications owing to their poor solubility, aggregation and insufficient selectivity for cancer cells. Catechol is an important pharmaceutical intermediate, playing important in vivo biological activity in medicine. Using catechol (pyrocatechin) as axial ligands, utilizing of the pharmaceutical effect of catechins, could improve the bioavailability, and achieve synergistic therapeutic effect in PDT. To address these issues, a novel catechol axially substituted tetra-α-(pentyloxy) titanium(IV) (TiPc(OC₅H₁₁)₄-Catechol) was synthesized. The structure of TiPc(OC₅H₁₁)₄-Catechol was characterized by elemental analysis, IR, ¹HNMR and MS methods. The photophysical properties of TiPc(OC₅H₁₁)₄ and TiPc(OC₅H₁₁)₄-Catechol have been studied by UV/Vis and steady-state fluorescence spectra. After being axially substituted with catechin groups, no obviously intensity and position of maximum wavelength in Q-band of TiPc(OC₅H₁₁)₄ and TiPc(OC₅H₁₁)₄-Catechol were observed. The fluorescence intensity of TiPc(OC₅H₁₁)₄ was stronger than that of TiPc(OC₅H₁₁)₄-Catechol, but the fluorescence lifetime of TiPc(OC₅H₁₁)₄-Catechol was longer than that of TiPc(OC₅H₁₁)₄. TiPc(OC₅H₁₁)₄-Catechol may be considered as a promising photosensitizer for PDT.

Citation Download Citation

Xinxin Yu, Ting Lin, Huafei Lv, Sujuan Pan, Shijun Wu, Di Zeng, Yufeng Jiang, Yuhua Wang, Hongqin Yang, Yide Huang, and Yiru Peng "Photophysical properties of catechol axially substituted tetra-α-(pentyloxy) titanium (IV) phthalocyanine", Proc. SPIE 10024, Optics in Health Care and Biomedical Optics VII, 100243P (31 October 2016); https://doi.org/10.1117/12.2246174

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available