Improving the signal-to-noise ratio in ultrasound-modulated optical tomography by a lock-in amplifier

Lili Zhu; Jingping Wu; Guimin Lin; Liangjun Hu; Hui Li

doi:10.1117/12.2246676

31 October 2016 Improving the signal-to-noise ratio in ultrasound-modulated optical tomography by a lock-in amplifier

Lili Zhu, Jingping Wu, Guimin Lin, Liangjun Hu, Hui Li

Proceedings Volume 10024, Optics in Health Care and Biomedical Optics VII; 100244O (2016) https://doi.org/10.1117/12.2246676
Event: SPIE/COS Photonics Asia, 2016, Beijing, China

Abstract

With high spatial resolution of ultrasonic location and high sensitivity of optical detection, ultrasound-modulated optical tomography (UOT) is a promising noninvasive biological tissue imaging technology. In biological tissue, the ultrasound-modulated light signals are very weak and are overwhelmed by the strong unmodulated light signals. It is a difficulty and key to efficiently pick out the weak modulated light from strong unmodulated light in UOT. Under the effect of an ultrasonic field, the scattering light intensity presents a periodic variation as the ultrasonic frequency changes. So the modulated light signals would be escape from the high unmodulated light signals, when the modulated light signals and the ultrasonic signal are processed cross correlation operation by a lock-in amplifier and without a chopper. Experimental results indicated that the signal-to-noise ratio of UOT is significantly improved by a lock-in amplifier, and the higher the repetition frequency of pulsed ultrasonic wave, the better the signal-to-noise ratio of UOT.

Citation Download Citation

Lili Zhu, Jingping Wu, Guimin Lin, Liangjun Hu, and Hui Li "Improving the signal-to-noise ratio in ultrasound-modulated optical tomography by a lock-in amplifier", Proc. SPIE 10024, Optics in Health Care and Biomedical Optics VII, 100244O (31 October 2016); https://doi.org/10.1117/12.2246676

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