Design and research for biosensing THz microfluidic chips

Ning Fan; Bo Su; Cong Zhang; Cunlin Zhang

doi:10.1117/12.2246354

3 November 2016 Design and research for biosensing THz microfluidic chips

Ning Fan, Bo Su, Cong Zhang, Cunlin Zhang

Proceedings Volume 10030, Infrared, Millimeter-Wave, and Terahertz Technologies IV; 100302F (2016) https://doi.org/10.1117/12.2246354
Event: SPIE/COS Photonics Asia, 2016, Beijing, China

Abstract

Many Biomolecules vibration frequencies are in terahertz (0.1THz-10THz) frequency range, so terahertz (THz) technology is an essential tool for detecting biological molecules. However, due to terahertz strongly absorbed by water, it is difficult to detect these molecules for biological and chemical liquid samples. Therefore, we present a novel detection method by combining terahertz technology with microfluidic technology. The strong absorption of water is effectively overcome by controlling the length that terahertz passes through liquid samples. What’s more, a higher signal to noise ratio is obtained through using less samples. In this paper, we designed a THz microfluidic chip that is easy to be fabricated by using the materials of Zeonor and polydimethylsiloxane (PDMS). Using terahertz time-domainspectroscopy (THz-TDS) system, we find that the chip has a high transmittance above 80% in the range from 0.2 THz to 2.6 THz. Then the THz spectra of deionized water and different kinds of solutions with different concentrations in the microfluidic chip were measured, respectively. In our research, it is found that different kinds of solutions have different transmission coefficients for THz. In addition, the THz transmission and absorption spectrum changes with the concentration of the same kind of solution.

Citation Download Citation

Ning Fan, Bo Su, Cong Zhang, and Cunlin Zhang "Design and research for biosensing THz microfluidic chips", Proc. SPIE 10030, Infrared, Millimeter-Wave, and Terahertz Technologies IV, 100302F (3 November 2016); https://doi.org/10.1117/12.2246354

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available