Integrated ZnO nanoparticles on paper-based microfluidic: toward efficient analytical device for glucose detection based on impedance and FTIR measurement

Rio Akbar Yuwono; Mokhammad Fahmi Izdiharruddin; Ruri Agung Wahyuono

doi:10.1117/12.2243827

11 November 2016 Integrated ZnO nanoparticles on paper-based microfluidic: toward efficient analytical device for glucose detection based on impedance and FTIR measurement

Rio Akbar Yuwono, Mokhammad Fahmi Izdiharruddin, Ruri Agung Wahyuono

Author Affiliations +

Proceedings Volume 10150, Second International Seminar on Photonics, Optics, and Its Applications (ISPhOA 2016); 1015011 (2016) https://doi.org/10.1117/12.2243827
Event: Second International Seminar on Photonics, Optics, and Its Applications (ISPhOA 2016), 2016, Bali, Indonesia

Abstract

Microfluidic paper-based analytical devices decorated with ZnO nanospherical (nanoSPs) aggregates (ZnO-μPAD) for glucose detection have been fabricated. ZnO nanoSPs were prepared by wet chemical synthesis and integrated on the optimized geometry of ZnO-μPAD has 0.2 and 0.4 mm of channel width and length, respectively. Glucose detection measurements were based on electrochemical and infrared transmission measurements. The glucose concentrations were adjusted as 5, 6.5, and 9 mmol, i.e. typical glucose level for normal, pre-diabetes and diabetes, in a mixture of ringer lactate as simulated biological fluid and red blood cells. ZnO nanoSPs in this study possess an average aggregate size of 160 nm formed by clustered ~ 18 nm crystallite size and ordered porous matrix as well as a surface area of 15 m²·g^-1.The separation process of the glucose sample on ZnO-μPAD requires approximately 45 s. The glucose detection results show that both electrochemical-based and FTIR-based measurements perform a linear measurement system (R² of 0.81 to 0.99) with a relatively high sensitivity. A linearly decreasing impedance spanning from 2.2 – 0.6 Ohm and linearly increasing ΔIR transmission spanning from 3 – 19% are obtained for glucose level ranging from 5 – 9 mmol.

Citation Download Citation

Rio Akbar Yuwono, Mokhammad Fahmi Izdiharruddin, and Ruri Agung Wahyuono "Integrated ZnO nanoparticles on paper-based microfluidic: toward efficient analytical device for glucose detection based on impedance and FTIR measurement", Proc. SPIE 10150, Second International Seminar on Photonics, Optics, and Its Applications (ISPhOA 2016), 1015011 (11 November 2016); https://doi.org/10.1117/12.2243827

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