Optoelectronic method for determining platinum in biological products

Simona Radu; Mihai Ionică; Radu Alexandru Macovei; Genica Caragea; Mărgărita Forje; Iulia Grecu; Marian Vlădescu; Oana Viscol

doi:10.1117/12.2248335

14 December 2016 Optoelectronic method for determining platinum in biological products

Simona Radu, Mihai Ionică, Radu Alexandru Macovei, Genica Caragea, Mărgărita Forje, Iulia Grecu, Marian Vlădescu, Oana Viscol

Author Affiliations +

Proceedings Volume 10010, Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies VIII; 100103J (2016) https://doi.org/10.1117/12.2248335
Event: Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies 2016, 2016, Constanta, Romania

Abstract

Of all platinum metals, platinum has the most uses and it’s the most abundant and most easily to be processed. Its use in auto catalysts results in environmental contamination of crowded cities and high-traffic roads. In medicine, Pt is used as a cytostatic drug. In order to study the degree of contamination of the population with Pt or the correctness of treatment with Pt, it has been developed a method for its determination from urine or blood samples with a system Graphite Furnance - Atomic Absorption Spectrometer, (GF-AAS) Varian. There are presented the methods of sampling processing for blood or urine that followed the digest of the organic matrix. In the determination of the operating parameters for the system GF-AAS, was aimed the reducing of the nonanatomic absorbance by optimizing the drying temperatures, the calcination and atomization temperatures and the removal of the nonanatomic absorbance with D2 lamp. As a result of the use of the method are presented the concentrations of Pt in the blood or urine of a group of patients in Bucharest, a city with heavy traffic of vehicles. GF-AAS method presented is sensitive, reproducible, and relatively easy to apply with an acceptable cost. With this method, the concentration of Pt can be determined from blood and urine, both in order to establish the degree of contamination with Pt and for monitoring cancer therapy with platinum compounds.

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Simona Radu, Mihai Ionică, Radu Alexandru Macovei, Genica Caragea, Mărgărita Forje, Iulia Grecu, Marian Vlădescu, and Oana Viscol "Optoelectronic method for determining platinum in biological products", Proc. SPIE 10010, Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies VIII, 100103J (14 December 2016); https://doi.org/10.1117/12.2248335

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