Through-skull vasculature assessment using fluorescence brain imaging on murine models at around 800 nm

Hanh N. D. Le; Yung-Tian A. Gau; Arman Rahmim; Dean F. Wong; Dwight E. Bergles; Jin U. Kang

doi:10.1117/12.2250240

8 February 2017 Through-skull vasculature assessment using fluorescence brain imaging on murine models at around 800 nm

Hanh N. D. Le, Yung-Tian A. Gau, Arman Rahmim, Dean F. Wong, Dwight E. Bergles, Jin U. Kang

Proceedings Volume 10051, Neural Imaging and Sensing; 100510M (2017) https://doi.org/10.1117/12.2250240
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

We describe a scanning near-infrared fluorescence imager for through-skull non-invasive brain imaging on live murine models. The captured photoluminescence feature through scattering media was enhanced using a high sensitivity scientific CMOS sensor with the obtained spatial resolution of 15.63 μm, depth of field of 5 mm and an average local signal-to-noise ratio of 37.5 dB.

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Citation Download Citation

Hanh N. D. Le, Yung-Tian A. Gau, Arman Rahmim, Dean F. Wong, Dwight E. Bergles, and Jin U. Kang "Through-skull vasculature assessment using fluorescence brain imaging on murine models at around 800 nm", Proc. SPIE 10051, Neural Imaging and Sensing, 100510M (8 February 2017); https://doi.org/10.1117/12.2250240

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