Image guided surgery using near-infrared fluorescence: road to clinical translation of novel probes for real time tumor visualization

Charlotte E. S. Hoogstins M.D.; Henricus J. M. Handgraaf M.D.; Leonora S. F. Boogerd M.D.; Jacobus Burggraaf M.D.; Alexander L. Vahrmeijer M.D.

doi:10.1117/12.2260520

8 February 2017 Image guided surgery using near-infrared fluorescence: road to clinical translation of novel probes for real time tumor visualization

Charlotte E. S. Hoogstins M.D., Henricus J. M. Handgraaf M.D., Leonora S. F. Boogerd M.D., Jacobus Burggraaf M.D., Alexander L. Vahrmeijer M.D.

Author Affiliations +

Proceedings Volume 10049, Molecular-Guided Surgery: Molecules, Devices, and Applications III; 100490X (2017) https://doi.org/10.1117/12.2260520
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

Fluorescence imaging is a novel intraoperative technique for guiding oncologic surgeons toward radical tumor resections. Application of various fluorescent agents in exploratory clinical trials has already yielded promising results. The field of fluorescence imaging must now move beyond the proof-of-concept phase toward clinical application and implementation. This shift encompasses several hurdles, including standardization, advanced-phase study endpoints, regulatory affairs and routine implementation, which need to be addressed by the community in close collaboration with all stakeholders. These challenges, and the possible actions to overcome them and promote and accelerate clinical implementation of fluorescence imaging, are summarized in this paper.

Conference Presentation

Citation Download Citation

Charlotte E. S. Hoogstins M.D., Henricus J. M. Handgraaf M.D., Leonora S. F. Boogerd M.D., Jacobus Burggraaf M.D., and Alexander L. Vahrmeijer M.D. "Image guided surgery using near-infrared fluorescence: road to clinical translation of novel probes for real time tumor visualization", Proc. SPIE 10049, Molecular-Guided Surgery: Molecules, Devices, and Applications III, 100490X (8 February 2017); https://doi.org/10.1117/12.2260520

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available