A tale of two photons: radioluminescence and its application in molecular imaging

Guillem Pratx

doi:10.1117/12.2256702

8 February 2017 A tale of two photons: radioluminescence and its application in molecular imaging

Guillem Pratx

Proceedings Volume 10049, Molecular-Guided Surgery: Molecules, Devices, and Applications III; 1004916 (2017) https://doi.org/10.1117/12.2256702
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

Optical and ionizing radiation are two physical ways in which we can probe the living world. Until recently, these forms of radiation were used in distinct imaging and therapeutic applications—radiation therapy, photodynamic therapy, X-ray imaging, and diffuse optical tomography, to name a few. It has now been recognized that physical phenomena in which ionizing radiation and light are inherently coupled may provide powerful new capabilities for imaging and treating diseases. This presentation will review the physics and applications of radioluminescence, with a particular focus on molecular imaging. One such method, X-ray luminescence computed tomography (XLCT), uses narrow kilovolt X-ray beams to stimulate optical emissions from biologically targeted radioluminescent nanoparticles, thus providing high-resolution images even deep in tissue. A different phenomenon, Cherenkov luminescence, can also be harnessed to localize radiopharmaceuticals in vivo, allowing surgeons to visualize the molecular status of the tissues they are resecting. Recent progress towards routine implantation of these methods will be reviewed and sources of endogenous radioluminescence signal will be discussed.

Conference Presentation

Citation Download Citation

Guillem Pratx "A tale of two photons: radioluminescence and its application in molecular imaging", Proc. SPIE 10049, Molecular-Guided Surgery: Molecules, Devices, and Applications III, 1004916 (8 February 2017); https://doi.org/10.1117/12.2256702

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