Assessing the mechanical anisotropy and hysteresis while cycling IOP of porcine eyes before and after CXL by noncontact optical coherence elastography

Manmohan Singh; Jiasong Li; Raksha Raghunathan; Zhaolong Han; Achuth Nair; Chih-Hao Liu; Salavt R. Aglyamov; Michael D. Twa; Kirill V. Larin

doi:10.1117/12.2253433

8 February 2017 Assessing the mechanical anisotropy and hysteresis while cycling IOP of porcine eyes before and after CXL by noncontact optical coherence elastography

Manmohan Singh, Jiasong Li, Raksha Raghunathan, Zhaolong Han, Achuth Nair, Chih-Hao Liu, Salavt R. Aglyamov, Michael D. Twa, Kirill V. Larin

Author Affiliations +

Proceedings Volume 10045, Ophthalmic Technologies XXVII; 1004504 (2017) https://doi.org/10.1117/12.2253433
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

Diseases such as keratoconus can alter the orientation of collagen fibrils in the cornea. Moreover, therapeutic interventions such as UV-A/riboflavin corneal collagen crosslinking (CXL) can alter the collagen fibril arrangement. Therefore, the anisotropic characteristics of the cornea can provide vital information about tissue integrity. In this work, we utilize noncontact elastic wave imaging optical coherence elastography (EWI-OCE) to assess the elastic anisotropy and hysteresis of in situ porcine corneas as various intraocular pressures (IOP). In addition, we evaluated the effects of CXL on the mechanical anisotropy and hysteresis. OCE measurements were made at stepped meridional angles, and a sliding window algorithm spatially mapped the elasticity. A modified planar anisotropy coefficient was utilized to quantify the elastic anisotropy of the corneas. The results show that the stiffness and elastic anisotropy of the corneas were significantly affected by CXL and IOP (P<0.001), but the hysteresis was not significant (P<0.05). Moreover, the changes in elasticity due to CXL were angle-dependent (P<0.005). However, the changes in mechanical anisotropy from CXL were not angle-dependent (P>0.05).

Citation Download Citation

Manmohan Singh, Jiasong Li, Raksha Raghunathan, Zhaolong Han, Achuth Nair, Chih-Hao Liu, Salavt R. Aglyamov, Michael D. Twa, and Kirill V. Larin "Assessing the mechanical anisotropy and hysteresis while cycling IOP of porcine eyes before and after CXL by noncontact optical coherence elastography", Proc. SPIE 10045, Ophthalmic Technologies XXVII, 1004504 (8 February 2017); https://doi.org/10.1117/12.2253433

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available