Raman spectroscopic characterization of urine of normal and cervical cancer subjects

Raja Pappu; Aruna Prakasarao; Koteeswaran Dornadula; Ganesan Singaravelu

doi:10.1117/12.2255878

14 February 2017 Raman spectroscopic characterization of urine of normal and cervical cancer subjects

Raja Pappu, Aruna Prakasarao, Koteeswaran Dornadula, Ganesan Singaravelu

Proceedings Volume 10054, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XV; 1005404 (2017) https://doi.org/10.1117/12.2255878
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

Cervical cancer is the fourth most common malignancy in female worldwide; the present method for diagnosis is the biopsy, Pap smear, colposcopy etc. To overcome the drawbacks of diagnosis an alternative technique is required, optical spectroscopy is a new technique where the discrimination of normal and cancer subjects provides valuable potential information in the diagnostic oncology at an early stage. Raman peaks in the spectra suggest interesting differences in various bio molecules. In this regard, non invasive optical detection of cervical cancer using urine samples by Raman Spectroscopy combined with LDA diagnostic algorithm yields an accuracy of 100% for original and cross validated group respectively. As the results were appreciable it is necessary to carry out the analysis for more number of samples to explore the facts hidden at different stages during the development of cervical cancer.

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Citation Download Citation

Raja Pappu, Aruna Prakasarao, Koteeswaran Dornadula, and Ganesan Singaravelu "Raman spectroscopic characterization of urine of normal and cervical cancer subjects", Proc. SPIE 10054, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XV, 1005404 (14 February 2017); https://doi.org/10.1117/12.2255878

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