Chip-on-the-tip ultra-compact flexible endoscopic epifluorescence video-microscope for in-vivo imaging in medical and biomedical fields

Gregor Matz; Bernhard Messerschmidt; Werner Göbel; Severin Filser; Christian Betz; Marcel Kunze; Sven Flaemig; André Ehrhardt; Klaus-Martin Irion; Jochen Herms; Herbert Gross

doi:10.1117/12.2251827

15 February 2017 Chip-on-the-tip ultra-compact flexible endoscopic epifluorescence video-microscope for in-vivo imaging in medical and biomedical fields

Gregor Matz, Bernhard Messerschmidt, Werner Göbel, Severin Filser, Christian Betz, Marcel Kunze, Sven Flaemig, André Ehrhardt, Klaus-Martin Irion, Jochen Herms, Herbert Gross

Author Affiliations +

Proceedings Volume 10040, Endoscopic Microscopy XII; 1004007 (2017) https://doi.org/10.1117/12.2251827
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

We demonstrate a flexible stand-alone, minimally invasive video-endomicroscope with an outer diameter of 1.6 mm and a length of the rigid tip of 6.7 mm that enables surgeons and biologists to image hardly accessible regions in-vivo in epifluorescence mode. The 60 mg light device improves state-of-the-art objectives by a double deflection approach using a side-fire fiber in combination with spherical microlenses, GRIN-lenses with a specific adapted gradient index profile and an extremely miniaturized chip-on-the-tip camera to achieve an excellent imaging quality. A high NA of 0.7 enables the observation of subcellular features within the entire field of view with a diameter of 183 μm, assure a bright and high-contrast image and promise a good overview during the intervention. Ex-vivo measurements of biological samples confirmed the functionality of the probe.

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Gregor Matz, Bernhard Messerschmidt, Werner Göbel, Severin Filser, Christian Betz, Marcel Kunze, Sven Flaemig, André Ehrhardt, Klaus-Martin Irion, Jochen Herms, and Herbert Gross "Chip-on-the-tip ultra-compact flexible endoscopic epifluorescence video-microscope for in-vivo imaging in medical and biomedical fields", Proc. SPIE 10040, Endoscopic Microscopy XII, 1004007 (15 February 2017); https://doi.org/10.1117/12.2251827

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KEYWORDS

In vivo imaging

Endoscopy

Biomedical optics

Cameras

Glasses

Endoscopes

Medical imaging

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