Minimally invasive optical biopsy for oximetry

Marieke A. van der Putten; James M. Brewer; Andrew R. Harvey

doi:10.1117/12.2253645

15 February 2017 Minimally invasive optical biopsy for oximetry

Marieke A. van der Putten, James M. Brewer, Andrew R. Harvey

Proceedings Volume 10040, Endoscopic Microscopy XII; 1004009 (2017) https://doi.org/10.1117/12.2253645
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

The study of localised oxygen saturation in blood vessels can shed light on the etiology and progression of many diseases with which hypoxia is associated. For example, hypoxia in the tendon has been linked to early stages of rheumatoid arthritis, an auto-immune inflammatory disease. Vascular oximetry of deep tissue presents significant challenges as vessels are not optically accessible. In this paper, we present a novel multispectral imaging technique for vascular oximetry, and recent developments made towards its adaptation for minimally invasive imaging. We present proof-of-concept of the system and illumination scheme as well as the analysis technique. We present results of a validation study performed in vivo on mice with acutely inflamed tendons. Adaptation of the technique for minimally invasive microendoscopy is also presented, along with preliminary results of minimally invasive ex vivo vascular oximetry.

Citation Download Citation

Marieke A. van der Putten, James M. Brewer, and Andrew R. Harvey "Minimally invasive optical biopsy for oximetry", Proc. SPIE 10040, Endoscopic Microscopy XII, 1004009 (15 February 2017); https://doi.org/10.1117/12.2253645

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