Stem cells as anticancer drug carrier to reduce the chemotherapy side effect

Hamideh Salehi; Siham Al-Arag; Elodie Middendorp; Csilla Gergley; Frederic Cuisinier

doi:10.1117/12.2251994

16 February 2017 Stem cells as anticancer drug carrier to reduce the chemotherapy side effect

Hamideh Salehi, Siham Al-Arag, Elodie Middendorp, Csilla Gergley, Frederic Cuisinier

Proceedings Volume 10068, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XV; 1006805 (2017) https://doi.org/10.1117/12.2251994
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

Chemotherapy used for cancer treatment, due to the lack of specificity of drugs, is associated to various damaging side effects that have severe impact on patients’ quality of life. Over the past 30 years, increasing efforts have been placed on optimizing chemotherapy dosing with the main goal of increasing antitumor efficacy while reducing drug-associated toxicity. A novel research shows that stem cells may act as a reservoir for the anticancer agent, which will subsequently release some of the drug’s metabolites, or even the drug in its original form, in vicinity of the cancer cells. These cells may play a dual role in controlling drug toxicity depending on their capacity to uptake and release the chemotherapeutic drug. In our study, we show that Dental Pulp Stem Cells DPSCs are able to rapidly uptake Paclitaxel PTX, and to release it in the culture medium in a time-dependent manner. This resulting conditioned culture medium is to be transferred to breast cancer cells, the MCF-7. By applying Confocal Raman Microscopy, the anticancer drug uptake by the MCF-7 was measured. Surprisingly, the cancer cells -without any direct contact with PTX- showed a drug uptake. This proves that the stem cells carried and delivered the anticancer drug without its modification. It could be a revolution in chemotherapy to avoid the drug’s side effects and increase its efficacy.

Conference Presentation

Citation Download Citation

Hamideh Salehi, Siham Al-Arag, Elodie Middendorp, Csilla Gergley, and Frederic Cuisinier "Stem cells as anticancer drug carrier to reduce the chemotherapy side effect", Proc. SPIE 10068, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XV, 1006805 (16 February 2017); https://doi.org/10.1117/12.2251994

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