Volumetric vessel reconstruction method for absolute blood flow velocity measurement in Doppler OCT images

Li Qi; Jiang Zhu; Aneeka M. Hancock; Cuixia Dai; Xuping Zhang; Ron D. Frostig; Zhongping Chen

doi:10.1117/12.2253309

17 February 2017 Volumetric vessel reconstruction method for absolute blood flow velocity measurement in Doppler OCT images

Li Qi, Jiang Zhu, Aneeka M. Hancock, Cuixia Dai, Xuping Zhang, Ron D. Frostig, Zhongping Chen

Author Affiliations +

Proceedings Volume 10053, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXI; 1005331 (2017) https://doi.org/10.1117/12.2253309
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

Doppler optical coherence tomography (DOCT) is considered one of the most promising functional imaging modalities for neuro biology research and has demonstrated the ability to quantify cerebral blood flow velocity at a high accuracy. However, the measurement of total absolute blood flow velocity (BFV) of major cerebral arteries is still a difficult problem since it not only relates to the properties of the laser and the scattering particles, but also relates to the geometry of both directions of the laser beam and the flow. In this paper, focusing on the analysis of cerebral hemodynamics, we presents a method to quantify the total absolute blood flow velocity in middle cerebral artery (MCA) based on volumetric vessel reconstruction from pure DOCT images. A modified region growing segmentation method is first used to localize the MCA on successive DOCT B-scan images. Vessel skeletonization, followed by an averaging gradient angle calculation method, is then carried out to obtain Doppler angles along the entire MCA. Once the Doppler angles are determined, the absolute blood flow velocity of each position on the MCA is easily found. Given a seed point position on the MCA, our approach could achieve automatic quantification of the fully distributed absolute BFV. Based on experiments conducted using a swept-source optical coherence tomography system, our approach could achieve automatic quantification of the fully distributed absolute BFV across different vessel branches in the rodent brain.

Citation Download Citation

Li Qi, Jiang Zhu, Aneeka M. Hancock, Cuixia Dai, Xuping Zhang, Ron D. Frostig, and Zhongping Chen "Volumetric vessel reconstruction method for absolute blood flow velocity measurement in Doppler OCT images", Proc. SPIE 10053, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXI, 1005331 (17 February 2017); https://doi.org/10.1117/12.2253309

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
4 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Doppler tomography

Blood circulation

Image segmentation

Optical coherence tomography

Doppler effect

Arteries

Velocity measurements

Show All Keywords

Keywords/Phrases

Search In:

Publication Years