Assessing the viscoelasticity of chicken liver by OCE and a Rayleigh wave model

Zhaolong Han; Chih-hao Liu; Manmohan Singh; Salavat R. Aglyamov; Raksha Raghunathan; Chen Wu; Kirill V. Larin

doi:10.1117/12.2253487

21 February 2017 Assessing the viscoelasticity of chicken liver by OCE and a Rayleigh wave model

Zhaolong Han, Chih-hao Liu, Manmohan Singh, Salavat R. Aglyamov, Raksha Raghunathan, Chen Wu, Kirill V. Larin

Proceedings Volume 10067, Optical Elastography and Tissue Biomechanics IV; 100671A (2017) https://doi.org/10.1117/12.2253487
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

This study investigates the feasibility of quantifying the viscoelasticity of soft tissues with a dynamic noncontact optical coherence elastography (OCE) technique coupled with a Rayleigh wave model. Spectral analysis of an air-pulse induced elastic wave as measured by OCE provided the elastic wave dispersion curve. The dispersion curve was fitted to an analytical solution of the Rayleigh wave model to determine the Young’s modulus and shear viscosity of samples. In order to validate the method, 10% gelatin phantoms with and without different concentrations of oil were prepared and tested by OCE and mechanical testing. Results demonstrated that the elasticities as assessed by the Rayleigh wave model generally agreed well with mechanical testing, and that the viscosity in the phantom with oil samples was higher than the phantoms without oil, which is in agreement with the literature. Further, this method was applied to quantify the viscoelasticity of chicken liver. The Young’s modulus was E=2.04±0.88 kPa and the shear viscosity was η=1.20±0.13 Pa·s with R²=0.96±0.04 between the OCE-measured dispersion curve and Rayleigh wave model analytical solution. Combining OCE and the Rayleigh wave model shows promise as an effective tool for noninvasively quantifying the viscoelasticity of soft tissues.

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Zhaolong Han, Chih-hao Liu, Manmohan Singh, Salavat R. Aglyamov, Raksha Raghunathan, Chen Wu, and Kirill V. Larin "Assessing the viscoelasticity of chicken liver by OCE and a Rayleigh wave model", Proc. SPIE 10067, Optical Elastography and Tissue Biomechanics IV, 100671A (21 February 2017); https://doi.org/10.1117/12.2253487

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KEYWORDS

Tissues

Liver

Protactinium

Statistical modeling

Elastography

Soft tissue optics

Statistical analysis

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