Optical focusing through biological tissue and tissue-mimicking phantoms up to 9.6 centimeters thick with digital optical phase conjugation

Yuecheng Shen; Yan Liu; Cheng Ma; Lihong V. Wang

doi:10.1117/12.2251052

21 February 2017 Optical focusing through biological tissue and tissue-mimicking phantoms up to 9.6 centimeters thick with digital optical phase conjugation

Yuecheng Shen, Yan Liu, Cheng Ma, Lihong V. Wang

Author Affiliations +

Proceedings Volume 10073, Adaptive Optics and Wavefront Control for Biological Systems III; 100730G (2017) https://doi.org/10.1117/12.2251052
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

Optical phase conjugation (OPC) based wavefront shaping techniques focus light through or within scattering media, which is critically important for deep-tissue optical imaging, manipulation, and therapy. However, to date, the sample thicknesses used in wavefront shaping experiments have been limited to only a few millimeters or several transport mean free paths. Here, by using a long-coherence-length laser and an optimized digital OPC system that efficiently delivers light power, we focused 532 nm light through tissue-mimicking phantoms up to 9.6 cm thick, as well as through ex vivo chicken breast tissue up to 2.5 cm thick.

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Citation Download Citation

Yuecheng Shen, Yan Liu, Cheng Ma, and Lihong V. Wang "Optical focusing through biological tissue and tissue-mimicking phantoms up to 9.6 centimeters thick with digital optical phase conjugation", Proc. SPIE 10073, Adaptive Optics and Wavefront Control for Biological Systems III, 100730G (21 February 2017); https://doi.org/10.1117/12.2251052

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