Multimodal optical imaging database from tumour brain human tissue: endogenous fluorescence from glioma, metastasis and control tissues

Fanny Poulon; Ali Ibrahim; Marc Zanello; Johan Pallud; Pascale Varlet; Fatima Malouki; Georges Abi Lahoud; Bertrand Devaux; Darine Abi Haidar

doi:10.1117/12.2249498

2 March 2017 Multimodal optical imaging database from tumour brain human tissue: endogenous fluorescence from glioma, metastasis and control tissues

Fanny Poulon, Ali Ibrahim, Marc Zanello, Johan Pallud, Pascale Varlet, Fatima Malouki, Georges Abi Lahoud, Bertrand Devaux, Darine Abi Haidar

Author Affiliations +

Proceedings Volume 10069, Multiphoton Microscopy in the Biomedical Sciences XVII; 100692M (2017) https://doi.org/10.1117/12.2249498
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

Eliminating time-consuming process of conventional biopsy is a practical improvement, as well as increasing the accuracy of tissue diagnoses and patient comfort. We addressed these needs by developing a multimodal nonlinear endomicroscope that allows real-time optical biopsies during surgical procedure. It will provide immediate information for diagnostic use without removal of tissue and will assist the choice of the optimal surgical strategy. This instrument will combine several means of contrast: non-linear fluorescence, second harmonic generation signal, reflectance, fluorescence lifetime and spectral analysis. Multimodality is crucial for reliable and comprehensive analysis of tissue. Parallel to the instrumental development, we currently improve our understanding of the endogeneous fluorescence signal with the different modalities that will be implemented in the stated. This endeavor will allow to create a database on the optical signature of the diseased and control brain tissues. This proceeding will present the preliminary results of this database on three types of tissues: cortex, metastasis and glioblastoma.

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Fanny Poulon, Ali Ibrahim, Marc Zanello, Johan Pallud, Pascale Varlet, Fatima Malouki, Georges Abi Lahoud, Bertrand Devaux, and Darine Abi Haidar "Multimodal optical imaging database from tumour brain human tissue: endogenous fluorescence from glioma, metastasis and control tissues", Proc. SPIE 10069, Multiphoton Microscopy in the Biomedical Sciences XVII, 100692M (2 March 2017); https://doi.org/10.1117/12.2249498

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KEYWORDS

Tissues

Luminescence

Tumors

Brain

Databases

Tissue optics

Second-harmonic generation

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