Deep-tissue photoacoustic imaging at 1064 nm using a contrast agent based on phosphorus phthalocyanine formulation

Depeng Wang; Yang Zhou; Yumiao Zhang; Jumin Geng; Yuehang Wang; Yuzhen Zhang; Timothy R. Cook; Jonathan F. Lovell; Jun Xia

doi:10.1117/12.2253320

3 March 2017 Deep-tissue photoacoustic imaging at 1064 nm using a contrast agent based on phosphorus phthalocyanine formulation

Depeng Wang, Yang Zhou, Yumiao Zhang, Jumin Geng, Yuehang Wang, Yuzhen Zhang, Timothy R. Cook, Jonathan F. Lovell, Jun Xia

Author Affiliations +

Proceedings Volume 10064, Photons Plus Ultrasound: Imaging and Sensing 2017; 100642X (2017) https://doi.org/10.1117/12.2253320
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

This study demonstrated the performance of photoacoustic imaging at 1064 nm using phosphorus phthalocyanine (P-Pc), a contrast agent with strong absorption at 1064 nm. Due to high maximum permissible exposure of 1064 nm laser light and strong absorbance of P-Pc at 1064 nm, we demonstrated an imaging depth of 11.6 cm in chicken breast tissue. For animal imaging, we used P-Pc to target tumor and to track intestine dynamics. Thus, using a contrast medium with extreme absorption at 1064 nm readily enables high quality photoacoustic imaging at exceptional depths.

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Depeng Wang, Yang Zhou, Yumiao Zhang, Jumin Geng, Yuehang Wang, Yuzhen Zhang, Timothy R. Cook, Jonathan F. Lovell, and Jun Xia "Deep-tissue photoacoustic imaging at 1064 nm using a contrast agent based on phosphorus phthalocyanine formulation", Proc. SPIE 10064, Photons Plus Ultrasound: Imaging and Sensing 2017, 100642X (3 March 2017); https://doi.org/10.1117/12.2253320

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