Combined optical and acoustic resolution photoacoustic microscopy

Mohesh Moothanchery; Manojit Pramanik

doi:10.1117/12.2251258

3 March 2017 Combined optical and acoustic resolution photoacoustic microscopy

Proceedings Volume 10064, Photons Plus Ultrasound: Imaging and Sensing 2017; 100644P (2017) https://doi.org/10.1117/12.2251258
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

Photoacoustic imaging is a fast growing in vivo imaging modality combining the optical absorption contrast and high spatial ultrasonic resolution. Using this technique deeper tissue penetration greater than optical mean free path (~1 mm in skin) is possible. Low resolution with deep penetration depth is possible utilizing acoustic focusing and high resolution with shallow imaging depth can be possible by optical focusing using different photoacoustic microscopy (PAM) systems. Here, we present a combined/switchable optical resolution and acoustic resolution photoacoustic microscopy (OR-AR-PAM) system capable of both high resolution and low resolution deep tissue imaging on the same sample. Lateral resolution of 3.9 μm using optical focusing and lateral resolution of 57 μm using acoustic focusing was successfully demonstrated using the combined system.

Citation Download Citation

Mohesh Moothanchery and Manojit Pramanik "Combined optical and acoustic resolution photoacoustic microscopy", Proc. SPIE 10064, Photons Plus Ultrasound: Imaging and Sensing 2017, 100644P (3 March 2017); https://doi.org/10.1117/12.2251258

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