Photonic nanojet engineering to achieve super-resolution in photoacoustic microscopy: a simulation study

Paul Kumar Upputuri; Mogana Sundari Krisnan; Mohesh Moothanchery; Manojit Pramanik

doi:10.1117/12.2250483

3 March 2017 Photonic nanojet engineering to achieve super-resolution in photoacoustic microscopy: a simulation study

Paul Kumar Upputuri, Mogana Sundari Krisnan, Mohesh Moothanchery, Manojit Pramanik

Proceedings Volume 10064, Photons Plus Ultrasound: Imaging and Sensing 2017; 100644S (2017) https://doi.org/10.1117/12.2250483
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

Label-free photoacoustic microscopy (PAM) with nanometric resolution is important to study cellular and sub-cellular structures, microcirculation systems, micro-vascularization, and tumor angiogenesis etc. But, the lateral resolution of a conventional microscopy is limited by optical diffraction. The photonic nanojet generated by silica microspheres can break this diffraction limit. Single silica sphere can provide narrow photonic jet, however its short length and short working distance limits its applications to surface imaging. It is possible to increase the length of the photonic nanojet and its working distance by optimizing the sphere design and its optical properties. In this work, we will present various sphere designs to achieve ultra-long and long-working distance photonic nanojets for far-field imaging. The nanojets thus generated will be used to demonstrate super-resolution photo-acoustic imaging using k-wave simulations. The study will provide new opportunities for many biomedical imaging applications that require finer resolution.

Citation Download Citation

Paul Kumar Upputuri, Mogana Sundari Krisnan, Mohesh Moothanchery, and Manojit Pramanik "Photonic nanojet engineering to achieve super-resolution in photoacoustic microscopy: a simulation study", Proc. SPIE 10064, Photons Plus Ultrasound: Imaging and Sensing 2017, 100644S (3 March 2017); https://doi.org/10.1117/12.2250483

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available