Temperature sensing of adipose tissue heating with the luminescent upconversion nanoparticles as nanothermometer: in vitro study

I. Yu. Yanina; E. K. Volkova; A. M. Zaharevich; J. G. Konyukhova; V. I. Kochubey; V. V. Tuchin

doi:10.1117/12.2250587

3 March 2017 Temperature sensing of adipose tissue heating with the luminescent upconversion nanoparticles as nanothermometer: in vitro study

I. Yu. Yanina, E. K. Volkova, A. M. Zaharevich, J. G. Konyukhova, V. I. Kochubey, V. V. Tuchin

Author Affiliations +

Proceedings Volume 10063, Dynamics and Fluctuations in Biomedical Photonics XIV; 100631A (2017) https://doi.org/10.1117/12.2250587
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

The luminescence spectra of upconversion nanoparticles (UCNPs) imbedded in fat tissue were measured in a wide temperature range, from room to human body and further to hyperthermic temperatures. The two types of synthesized UCNP [NaYF₄:Yb³⁺, Er³⁺] specimens, namely, powdered as-is and embedded into polymer film, were used. The results show that the luminescence of UCNPs placed under the adipose tissue layer is reasonably good sensitive to temperature change and reflects phase transitions of lipids in tissue cells. The most likely, multiple phase transitions are associated with the different components of fat cells such as phospholipids of cell membrane and lipids of fat droplets. In the course of fat cell heating, lipids of fat droplet first transit from a crystalline form to a liquid crystal form and then to a liquid form, which is characterized by much less scattering. The phase transitions of lipids were observed as the changes of the slope of the temperature dependence of UCNP luminescence intensity. The obtained results confirm a high sensitivity of the luminescent UCNPs to the temperature variations within tissues and show a strong potential for providing a controllable tissue thermolysis.

Citation Download Citation

I. Yu. Yanina, E. K. Volkova, A. M. Zaharevich, J. G. Konyukhova, V. I. Kochubey, and V. V. Tuchin "Temperature sensing of adipose tissue heating with the luminescent upconversion nanoparticles as nanothermometer: in vitro study", Proc. SPIE 10063, Dynamics and Fluctuations in Biomedical Photonics XIV, 100631A (3 March 2017); https://doi.org/10.1117/12.2250587

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available