Experimental investigation of a HOPG crystal fan for x-ray fluorescence molecular imaging

Tanja Rosentreter; Bernhard Müller; Helmut Schlattl; Christoph Hoeschen

doi:10.1117/12.2253858

9 March 2017 Experimental investigation of a HOPG crystal fan for x-ray fluorescence molecular imaging

Tanja Rosentreter, Bernhard Müller, Helmut Schlattl, Christoph Hoeschen

Proceedings Volume 10132, Medical Imaging 2017: Physics of Medical Imaging; 101325P (2017) https://doi.org/10.1117/12.2253858
Event: SPIE Medical Imaging, 2017, Orlando, Florida, United States

Abstract

Imaging x-ray fluorescence generally generates a conflict between the best image quality or highest sensitivity and lowest possible radiation dose. Consequently many experimental studies investigating the feasibility of this molecular imaging method, deal with either monochromatic x-ray sources that are not practical in clinical environment or accept high x-ray doses in order to maintain the advantage of high sensitivity and producing high quality images. In this work we present a x-ray fluorescence imaging setup using a HOPG crystal fan construction consisting of a Bragg reflecting analyzer array together with a scatter reducing radial collimator. This method allows for the use of polychromatic x-ray tubes that are in general easily accessible in contrast to monochromatic x-ray sources such as synchrotron facilities. Moreover this energy-selecting device minimizes the amount of Compton scattered photons while simultaneously increasing the fluorescence signal yield, thus significantly reducing the signal to noise ratio. The aim is to show the feasibility of this approach by measuring the Bragg reflected Kα fluorescence signal of an object containing an iodine solution using a large area detector with moderate energy resolution. Contemplating the anisotropic energy distribution of background scattered x-rays we compare the detection sensitivity, applying two different detector angular configurations. Our results show that even for large area detectors with limited energy resolution, iodine concentrations of 0.12 % can be detected. However, the potentially large scan times and therefore high radiation dose need to be decreased in further investigations.

Citation Download Citation

Tanja Rosentreter, Bernhard Müller, Helmut Schlattl, and Christoph Hoeschen "Experimental investigation of a HOPG crystal fan for x-ray fluorescence molecular imaging", Proc. SPIE 10132, Medical Imaging 2017: Physics of Medical Imaging, 101325P (9 March 2017); https://doi.org/10.1117/12.2253858

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available