Chromatic multifocal pupillometer for objective early diagnosis of mild cognitive impairment

Ygal Rotenstreich; Daniel Ben-Ner; Inbal Sharvit-Ginon; Ramit Ravona-Springer; Michal Beeri; Ifat Sher

doi:10.1117/12.2251428

23 March 2017 Chromatic multifocal pupillometer for objective early diagnosis of mild cognitive impairment

Ygal Rotenstreich, Daniel Ben-Ner, Inbal Sharvit-Ginon, Ramit Ravona-Springer, Michal Beeri, Ifat Sher

Proceedings Volume 10045, Ophthalmic Technologies XXVII; 100451Z (2017) https://doi.org/10.1117/12.2251428
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

The pupil responses of 15 cognitively normal subjects (ages 60-74) were examined in response to 76 focal red and blue light stimuli using a chromatic multifocal pupillometer (CMP). Subjects with low cognitive scores as determined as by Montreal Cognitive Assessment testing, presented significantly weaker and sluggish pupil responses in peripheral and central locations of the visual field in response to red and blue light. Our findings suggests that the CMP may present a novel objective, non-invasive, low cost technique for early diagnosis of cognitive decline that may serve for Alzheimer Disease prevention and as sensitive outcome measure of therapeutic effects.

Citation Download Citation

Ygal Rotenstreich, Daniel Ben-Ner, Inbal Sharvit-Ginon, Ramit Ravona-Springer, Michal Beeri, and Ifat Sher "Chromatic multifocal pupillometer for objective early diagnosis of mild cognitive impairment", Proc. SPIE 10045, Ophthalmic Technologies XXVII, 100451Z (23 March 2017); https://doi.org/10.1117/12.2251428

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