Non-invasive control of influence of polyethylene glycol on transport function of fluorescent colored liposomal nanoparticles

O. Stelmashchuk; E. Zherebtsov; A. Zherebtsova; E. Kuznetsova; A. Vinokurov; A. Dunaev; A. Mamoshin; I. Snimshchikova; A. Borsukov; A. Bykov; I. Meglinski

doi:10.1117/12.2269379

24 March 2017 Non-invasive control of influence of polyethylene glycol on transport function of fluorescent colored liposomal nanoparticles

O. Stelmashchuk, E. Zherebtsov, A. Zherebtsova, E. Kuznetsova, A. Vinokurov, A. Dunaev, A. Mamoshin, I. Snimshchikova, A. Borsukov, A. Bykov, I. Meglinski

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Proceedings Volume 10336, Saratov Fall Meeting 2016: Optical Technologies in Biophysics and Medicine XVIII; 1033604 (2017) https://doi.org/10.1117/12.2269379
Event: Saratov Fall Meeting 2016: Fourth International Symposium on Optics and Biophotonics, 2016, Saratov, Russian Federation

Abstract

The studies were carried out on groups of clinically healthy mice line of outbred CD-1 stock. The model animals were divided into 2 groups and received experimental liposomal formulations. Using the method of fluorescence spectroscopy, we investigated the effectiveness of penetration into the circulatory system of fluorescently stained liposomes with polyethylene glycol (PEG) and without PEG when administered orally. Fluorescence channel with a fiber probe series of multifunctional laser non-invasive diagnostic system “LAKK-M” (SPE “LAZMA” Ltd, Russia) was used as the measuring equipment.

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O. Stelmashchuk, E. Zherebtsov, A. Zherebtsova, E. Kuznetsova, A. Vinokurov, A. Dunaev, A. Mamoshin, I. Snimshchikova, A. Borsukov, A. Bykov, and I. Meglinski "Non-invasive control of influence of polyethylene glycol on transport function of fluorescent colored liposomal nanoparticles", Proc. SPIE 10336, Saratov Fall Meeting 2016: Optical Technologies in Biophysics and Medicine XVIII, 1033604 (24 March 2017); https://doi.org/10.1117/12.2269379

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KEYWORDS

Luminescence

Nanoparticles

Fluorescence spectroscopy

Fluorescent markers

Diagnostics

Fiber lasers

Particles

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