Wavefront correction enables vibrational imaging of bacteria with multimode fibre probes

Ivan Gusachenko; Mingzhou Chen; Kishan Dholakia

doi:10.1117/12.2274974

18 April 2017 Wavefront correction enables vibrational imaging of bacteria with multimode fibre probes

Ivan Gusachenko, Mingzhou Chen, Kishan Dholakia

Proceedings Volume 10251, Biomedical Imaging and Sensing Conference; 1025104 (2017) https://doi.org/10.1117/12.2274974
Event: SPIE Technologies and Applications of Structured Light, 2017, Yokohama, Japan

Abstract

Raman spectroscopy is a valuable tool for non-invasive and label-free identification of sample chemical composition. Recently a few miniaturized optical probes emerged driven by the need to address areas of difficult access, such as in endoscopy. However, imaging modality is still out of reach for most of them. Separately, recent advances in wavefront shaping enabled different microscopies to be applied in various complex media including multimode fibers. Here we present the first and thinnest to date Raman fiber imaging probe based on wavefront shaping through a single multimode fiber without use of any additional optics. We image agglomerates of bacteria and pharmaceuticals to demonstrate the capability of our method. This work paves the way towards compact and flexible Raman endoscopy.

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Ivan Gusachenko, Mingzhou Chen, and Kishan Dholakia "Wavefront correction enables vibrational imaging of bacteria with multimode fibre probes", Proc. SPIE 10251, Biomedical Imaging and Sensing Conference, 1025104 (18 April 2017); https://doi.org/10.1117/12.2274974

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KEYWORDS

Raman spectroscopy

Wavefronts

Multimode fibers

Bacteria

Spatial light modulators

Endoscopy

Imaging spectroscopy

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