Label-free characterization of degenerative changes in articular cartilage by Raman spectroscopy

Yusuke Oshima; Mayu Akehi; Hiroshi Kiyomatsu; Hiromasa Miura

doi:10.1117/12.2275047

18 April 2017 Label-free characterization of degenerative changes in articular cartilage by Raman spectroscopy

Yusuke Oshima, Mayu Akehi, Hiroshi Kiyomatsu, Hiromasa Miura

Proceedings Volume 10251, Biomedical Imaging and Sensing Conference; 1025108 (2017) https://doi.org/10.1117/12.2275047
Event: SPIE Technologies and Applications of Structured Light, 2017, Yokohama, Japan

Abstract

Osteoarthritis (OA) is very common joint disease in the aging population. Main symptom of OA is accompanied by degenerative changes of articular cartilage. Raman spectroscopy is a label-free technique which enables to analyze molecular composition in degenerative cartilage. We generated an animal OA model surgically induced by knee joint instability and performed Raman spectroscopic analysis for the articular cartilage. In the result, Raman spectral data of the articular cartilage showed drastic changes in comparison between OA and control side. The relative intensity of phosphate band increases in the degenerative cartilage.

Citation Download Citation

Yusuke Oshima, Mayu Akehi, Hiroshi Kiyomatsu, and Hiromasa Miura "Label-free characterization of degenerative changes in articular cartilage by Raman spectroscopy", Proc. SPIE 10251, Biomedical Imaging and Sensing Conference, 1025108 (18 April 2017); https://doi.org/10.1117/12.2275047

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