Adaptive optical microscope for brain imaging in vivo

Kai Wang

doi:10.1117/12.2274950

18 April 2017 Adaptive optical microscope for brain imaging in vivo

Kai Wang

Proceedings Volume 10251, Biomedical Imaging and Sensing Conference; 102510H (2017) https://doi.org/10.1117/12.2274950
Event: SPIE Technologies and Applications of Structured Light, 2017, Yokohama, Japan

Abstract

The optical heterogeneity of biological tissue imposes a major limitation to acquire detailed structural and functional information deep in the biological specimens using conventional microscopes. To restore optimal imaging performance, we developed an adaptive optical microscope based on direct wavefront sensing technique. This microscope can reliably measure and correct biological samples induced aberration. We demonstrated its performance and application in structural and functional brain imaging in various animal models, including fruit fly, zebrafish and mouse.

Citation Download Citation

Kai Wang "Adaptive optical microscope for brain imaging in vivo", Proc. SPIE 10251, Biomedical Imaging and Sensing Conference, 102510H (18 April 2017); https://doi.org/10.1117/12.2274950

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