Non-label bioimaging utilizing scattering lights

Tomonobu M. Watanabe; Taro Ichimura; Hideaki Fujita

doi:10.1117/12.2269413

18 April 2017 Non-label bioimaging utilizing scattering lights

Tomonobu M. Watanabe, Taro Ichimura, Hideaki Fujita

Proceedings Volume 10251, Biomedical Imaging and Sensing Conference; 102510O (2017) https://doi.org/10.1117/12.2269413
Event: SPIE Technologies and Applications of Structured Light, 2017, Yokohama, Japan

Abstract

Optical microscopy is an indispensable tool for medical and life sciences. Especially, the microscopes utilized with scattering light offer a detailed internal observation of living specimens in real time because of their non-labeling and non-invasive capability. We here focus on two kinds of scattering lights, Raman scattering light and second harmonic generation light. Raman scattering light includes the information of all the molecular vibration modes of the molecules, and can be used to distinguish types and/or state of cell. Second harmonic generation light is derived from electric polarity of proteins in the specimen, and enables to detect their structural change. In this conference, we would like to introduce our challenges to extract biological information from those scattering lights.

Citation Download Citation

Tomonobu M. Watanabe, Taro Ichimura, and Hideaki Fujita "Non-label bioimaging utilizing scattering lights", Proc. SPIE 10251, Biomedical Imaging and Sensing Conference, 102510O (18 April 2017); https://doi.org/10.1117/12.2269413

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KEYWORDS

Light scattering

Raman spectroscopy

Second-harmonic generation

Raman scattering

Scattering

Molecules

Microscopes

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