Biomolecular detection with an interferometric microfiber-capillary optofluidic sensor

Lili Liang; Long Jin; Bai-Ou Guan

doi:10.1117/12.2264772

23 April 2017 Biomolecular detection with an interferometric microfiber-capillary optofluidic sensor

Lili Liang, Long Jin, Bai-Ou Guan

Proceedings Volume 10323, 25th International Conference on Optical Fiber Sensors; 103230Y (2017) https://doi.org/10.1117/12.2264772
Event: 25th International Conference on Optical Fiber Sensors, 2017, Jeju, Korea, Republic of

Abstract

We have developed a chip-scale optofluidic sensor for biomolecular detection, by tapering laterally aligned silica microfiber and capillary to form a modal interferometer. With the pre-immobilization of DNA probes, the sensor is capable of selectively detecting single-stranded microRNA-let7a (molecular weight: 6.5 k) by measuring the spectral shift of the interferometric spectrum. A log-linear response from 2 nM to 20 μM and a minimum detectable concentration of 212 pM (1.43 ng/mL) have been achieved. The sensor is promising for future diagnosis applications due to its high sensitivity, resistance to environmental perturbations, improved portability, and intrinsic connection to fiber optic measurement.

Citation Download Citation

Lili Liang, Long Jin, and Bai-Ou Guan "Biomolecular detection with an interferometric microfiber-capillary optofluidic sensor", Proc. SPIE 10323, 25th International Conference on Optical Fiber Sensors, 103230Y (23 April 2017); https://doi.org/10.1117/12.2264772

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