Visualization of drug distribution of topical minocycline in human facial skin with fluorescence microscopy (Conference Presentation)

Maiko Hermsmeier; Tanvee Sawant; Diana Lac; Akira Yamamoto; Xin Chen; Usha Nagavarapu; Conor L. Evans; Kin Foong Chan

doi:10.1117/12.2256621

19 April 2017 Visualization of drug distribution of topical minocycline in human facial skin with fluorescence microscopy (Conference Presentation)

Maiko Hermsmeier, Tanvee Sawant, Diana Lac, Akira Yamamoto, Xin Chen, Usha Nagavarapu, Conor L. Evans, Kin Foong Chan

Author Affiliations +

Proceedings Volume 10046, Visualizing and Quantifying Drug Distribution in Tissue; 100460A (2017) https://doi.org/10.1117/12.2256621
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

Minocycline is an antibiotic regularly prescribed to treat acne vulgaris. The only commercially available minocycline comes in an oral dosage form, which often results in systemic adverse effects. A topical minocycline composition (BPX-01) was developed to provide localized and targeted delivery to the epidermis and pilosebaceous unit where acne-related bacteria, Propionibacterium acnes (P. acnes), reside. As minocycline is a known fluorophore, fluorescence microscopy was performed to investigate its potential use in visualizing minocycline distribution within tissues. BPX-01 with various concentrations of minocycline, was applied topically to freshly excised human facial skin specimens. Spatial distribution of minocycline and its fluorescence intensity within the stratum corneum, epidermis, dermis, and pilosebaceous unit were assessed. The resulting fluorescence intensity data as a function of minocycline concentration may indicate clinically relevant therapeutic doses of topical BPX-01 needed to kill P. acnes and reduce inflammation for successful clinical outcomes.

Conference Presentation

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Maiko Hermsmeier, Tanvee Sawant, Diana Lac, Akira Yamamoto, Xin Chen, Usha Nagavarapu, Conor L. Evans, and Kin Foong Chan "Visualization of drug distribution of topical minocycline in human facial skin with fluorescence microscopy (Conference Presentation)", Proc. SPIE 10046, Visualizing and Quantifying Drug Distribution in Tissue, 100460A (19 April 2017); https://doi.org/10.1117/12.2256621

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KEYWORDS

Luminescence

Visualization

Microscopy

Skin

Tissues

Bacteria

Inflammation

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