New chemical probe technologies: applications to imaging and drug discovery (Conference Presentation)

Matthew Bogyo

doi:10.1117/12.2257636

19 April 2017 New chemical probe technologies: applications to imaging and drug discovery (Conference Presentation)

Matthew Bogyo

Proceedings Volume 10049, Molecular-Guided Surgery: Molecules, Devices, and Applications III; 100490N (2017) https://doi.org/10.1117/12.2257636
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

Proteases are enzymes that play pathogenic roles in many common human diseases such as cancer, asthma, arthritis, atherosclerosis and infection by pathogens. Tools to dynamically monitor their activity can be used as diagnostic agents, as imaging contrast agents for intra-operative image guidance and for the identification of novel classes of protease-targeted drugs. I will describe our efforts to design and synthesize small molecule probes that produce a fluorescent signal upon binding to a protease target. We have identified probes that show tumor-specific retention, fast activation kinetics, and rapid systemic distribution making them useful for real-time fluorescence guided tumor resection and other diagnostic imaging applications.

Conference Presentation

Citation Download Citation

Matthew Bogyo "New chemical probe technologies: applications to imaging and drug discovery (Conference Presentation)", Proc. SPIE 10049, Molecular-Guided Surgery: Molecules, Devices, and Applications III, 100490N (19 April 2017); https://doi.org/10.1117/12.2257636

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