Magnetic nanotubes for drug delivery

Mouli Ramasamy; Prashanth Shyam Kumar; Vijay K. Varadan

doi:10.1117/12.2264367

24 April 2017 Magnetic nanotubes for drug delivery

Mouli Ramasamy, Prashanth Shyam Kumar, Vijay K. Varadan

Proceedings Volume 10167, Nanosensors, Biosensors, Info-Tech Sensors and 3D Systems 2017; 1016715 (2017) https://doi.org/10.1117/12.2264367
Event: SPIE Smart Structures and Materials + Nondestructive Evaluation and Health Monitoring, 2017, Portland, Oregon, United States

Abstract

Magnetic nanotubes hold the potential for neuroscience applications because of their capability to deliver chemicals or biomolecules and the feasibility of controlling the orientation or movement of these magnetic nanotubes by an external magnetic field thus facilitating directed growth of neurites. Therefore, we sought to investigate the effects of laminin treated magnetic nanotubes and external alternating magnetic fields on the growth of dorsal root ganglion (DRG) neurons in cell culture. Magnetic nanotubes were synthesized by a hydrothermal method and characterized to confirm their hollow structure, the hematite and maghemite phases, and the magnetic properties. DRG neurons were cultured in the presence of magnetic nanotubes under alternating magnetic fields. Electron microscopy showed a close interaction between magnetic nanotubes and the growing neurites Phase contrast microscopy revealed live growing neurons suggesting that the combination of the presence of magnetic nanotubes and the alternating magnetic field were tolerated by DRG neurons. The synergistic effect, from both laminin treated magnetic nanotubes and the applied magnetic fields on survival, growth and electrical activity of the DRG neurons are currently being investigated.

Conference Presentation

Citation Download Citation

Mouli Ramasamy, Prashanth Shyam Kumar, and Vijay K. Varadan "Magnetic nanotubes for drug delivery", Proc. SPIE 10167, Nanosensors, Biosensors, Info-Tech Sensors and 3D Systems 2017, 1016715 (24 April 2017); https://doi.org/10.1117/12.2264367

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available