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24 April 2017 Computationally-efficient optical coherence elastography to assess degenerative osteoarthritis based on ultrasound-induced fringe washout (Conference Presentation)
Minh Q. Tong, M. Monirul Hasan, Patrick D. Gregory, Jasmine Shah, B. Hyle Park, Koji Hirota, Junze Liu, Andy Choi, Karen Low, Jin Nam
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Proceedings Volume 10067, Optical Elastography and Tissue Biomechanics IV; 100670U (2017) https://doi.org/10.1117/12.2253427
Event: SPIE BiOS, 2017, San Francisco, California, United States
Abstract
We demonstrate a computationally-efficient optical coherence elastography (OCE) method based on fringe washout. By introducing ultrasound in alternating depth profile, we can obtain information on the mechanical properties of a sample within acquisition of a single image. This can be achieved by simply comparing the intensity in adjacent depth profiles in order to quantify the degree of fringe washout. Phantom agar samples with various densities were measured and quantified by our OCE technique, the correlation to Young’s modulus measurement by atomic force micrscopy (AFM) were observed. Knee cartilage samples of monoiodo acetate-induced arthiritis (MIA) rat models were utilized to replicate cartilage damages where our proposed OCE technique along with intensity and birefringence analyses and AFM measurements were applied. The results indicate that our OCE technique shows a correlation to the techniques as polarization-sensitive OCT, AFM Young’s modulus measurements and histology were promising. Our OCE is applicable to any of existing OCT systems and demonstrated to be computationally-efficient.
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Minh Q. Tong, M. Monirul Hasan, Patrick D. Gregory, Jasmine Shah, B. Hyle Park, Koji Hirota, Junze Liu, Andy Choi, Karen Low, and Jin Nam "Computationally-efficient optical coherence elastography to assess degenerative osteoarthritis based on ultrasound-induced fringe washout (Conference Presentation)", Proc. SPIE 10067, Optical Elastography and Tissue Biomechanics IV, 100670U (24 April 2017); https://doi.org/10.1117/12.2253427
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KEYWORDS
Elastography
Atomic force microscopy
Coherence (optics)
Cartilage
Optical coherence tomography
Tissue optics
Birefringence
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