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24 April 2017 DotLens smartphone microscopy for biological and biomedical applications (Conference Presentation)
Yu-Lung Sung, Fusheng Zhao, Wei-Chuan Shih
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Proceedings Volume 10072, Optical Diagnostics and Sensing XVII: Toward Point-of-Care Diagnostics; 100720J (2017) https://doi.org/10.1117/12.2252528
Event: SPIE BiOS, 2017, San Francisco, California, United States
Abstract
Recent advances in inkjet-printed optics have created a new class of lens fabrication technique. Lenses with a tunable geometry, magnification, and focal length can be fabricated by dispensing controlled amounts of liquid polymer onto a heated surface. This fabrication technique is highly cost-effective, and can achieve optically smooth surface finish. Dubbed DotLens, a single of which weighs less than 50 mg and occupies a volume less than 50 μL. DotLens can be attached onto any smartphone camera akin to a contact lens, and enable smartphones to obtain image resolution as fine as 1 µm. The surface curvature modifies the optical path of light to the image sensor, and enables the camera to focus as close as 2 mm. This enables microscopic imaging on a smartphone without any additional attachments, and has shown great potential in mobile point-of-care diagnostic systems, particularly for histology of tissue sections and cytology of blood cells. DotLens Smartphone Microscopy represents an innovative approach fundamentally different from other smartphone microscopes. In this paper, we describe the application and performance of DotLens smartphone microscopy in biological and biomedical research. In particular, we show recent results from images collected from pathology tissue slides with cancer features. In addition, we show performance in cytological analysis of blood smear. This tool has empowered Citizen Science investigators to collect microscopic images from various interesting objects.
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Yu-Lung Sung, Fusheng Zhao, and Wei-Chuan Shih "DotLens smartphone microscopy for biological and biomedical applications (Conference Presentation)", Proc. SPIE 10072, Optical Diagnostics and Sensing XVII: Toward Point-of-Care Diagnostics, 100720J (24 April 2017); https://doi.org/10.1117/12.2252528
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KEYWORDS
Microscopy
Biomedical optics
Blood
Cameras
Fabrication
Imaging systems
Tissues
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