CONFERENCE PROCEEDINGS
Advanced Search
Home > Proceedings > Volume 10076 > Article
Presentation
24 April 2017 Recent advances in high-throughput QCL-based infrared microspectral imaging (Conference Presentation)
Jeremy A. Rowlette, Edeline Fotheringham, David Nichols, Miles J. Weida, Justin Kane, Allen Priest, David B. Arnone, Benjamin Bird, William B. Chapman, David B. Caffey, Paul Larson, Timothy Day
Author Affiliations +
Proceedings Volume 10076, High-Speed Biomedical Imaging and Spectroscopy: Toward Big Data Instrumentation and Management II; 100760N (2017) https://doi.org/10.1117/12.2254478
Event: SPIE BiOS, 2017, San Francisco, California, United States
Abstract
The field of infrared spectral imaging and microscopy is advancing rapidly due in large measure to the recent commercialization of the first high-throughput, high-spatial-definition quantum cascade laser (QCL) microscope. Having speed, resolution and noise performance advantages while also eliminating the need for cryogenic cooling, its introduction has established a clear path to translating the well-established diagnostic capability of infrared spectroscopy into clinical and pre-clinical histology, cytology and hematology workflows. Demand for even higher throughput while maintaining high-spectral fidelity and low-noise performance continues to drive innovation in QCL-based spectral imaging instrumentation. In this talk, we will present for the first time, recent technological advances in tunable QCL photonics which have led to an additional 10X enhancement in spectral image data collection speed while preserving the high spectral fidelity and SNR exhibited by the first generation of QCL microscopes. This new approach continues to leverage the benefits of uncooled microbolometer focal plane array cameras, which we find to be essential for ensuring both reproducibility of data across instruments and achieving the high-reliability needed in clinical applications. We will discuss the physics underlying these technological advancements as well as the new biomedical applications these advancements are enabling, including automated whole-slide infrared chemical imaging on clinically relevant timescales.
Conference Presentation
© (2017) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation Download Citation
Jeremy A. Rowlette, Edeline Fotheringham, David Nichols, Miles J. Weida, Justin Kane, Allen Priest, David B. Arnone, Benjamin Bird, William B. Chapman, David B. Caffey, Paul Larson, and Timothy Day "Recent advances in high-throughput QCL-based infrared microspectral imaging (Conference Presentation)", Proc. SPIE 10076, High-Speed Biomedical Imaging and Spectroscopy: Toward Big Data Instrumentation and Management II, 100760N (24 April 2017); https://doi.org/10.1117/12.2254478
ACCESS THE FULL ARTICLE
ORGANIZATIONAL
Sign in with credentials provided by your organization.
INSTITUTIONAL
Select your institution to access the SPIE Digital Library.
SELECT YOUR INSTITUTION
PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
PERSONAL SIGN IN
No SPIE Account? Create one
PURCHASE THIS CONTENT
SUBSCRIBE TO DIGITAL LIBRARY
50 downloads per 1-year subscription
Members: $195
Non-members: $335 ADD TO CART
25 downloads per 1 - year subscription
Members: $145
Non-members: $250 ADD TO CART
PURCHASE SINGLE ARTICLE
Includes PDF, HTML & Video, when available
Members: $17.00
Non-members: $21.00 ADD TO CART
PROCEEDINGS
 PRESENTATION
WATCH
PRESENTATION SAVE TO MY LIBRARY
GET CITATION
Advertisement
Advertisement
KEYWORDS
Infrared imaging
Infrared radiation
Quantum cascade lasers
Imaging spectroscopy
Image enhancement
Microscopes
Biomedical optics
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top