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Proceedings Article

Topical photosan-mediated photodynamic therapy for DMBA-induced hamster buccal pouch early cancer lesions: an in vivo study

[+] Author Affiliations
Yih-Chih Hsu, Walter Hong-Shong Chang

Chung Yuan Christian Univ. (Taiwan)

Junn-Liang Chang, Kuang-Ting Liu

Taoyuan Armed Forces General Hospital (Taiwan)

Chun-Pin Chiang

National Taiwan Univ. (Taiwan)

Chung-Ji Liu

National Yang-Ming Univ. (Taiwan) and Taiwan Mackay Memorial Hospital (Taiwan) and Nursing and Management College (Taiwan)

Chih-Ping Chen

Taipei Mackay Memorial Hospital (Taiwan)

Proc. SPIE 7900, Biophotonics and Immune Responses VI, 790004 (February 10, 2011); doi:10.1117/12.879555
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From Conference Volume 7900

  • Biophotonics and Immune Responses VI
  • Wei R. Chen
  • San Francisco, California, USA | January 22, 2011

abstract

Oral cancer has becomes the most prominent cancer disease in recent years in Taiwan. The reason is the betel nut chewing habit combing with smoking and alcohol-drinking lifestyle of people results in oral cancer becomes the fastest growth incident cancer amongst other major cancer diseases. In previous studies showed that photosan, haematoporphyrin derivative (HPD), has demonstrated effective PDT results on human head and neck disease studies. To avoid the systemic phototoxic effect of photosan, this study was designed to use a topical photosan-mediated PDT for treatment of DMBA-induced hamster buccal pouch cancerous lesions. DMBA was applied to one of the buccal pouches of hamsters thrice a week for 10 to 12 weeks. Cancerous lesions were induced and proven by histological examination. These DMBA-induced cancerous lesions were used for testing the efficacy of topical photosan-mediated PDT. Before PDT, fluorescence spectroscopy was used to determine when photosan reached its peak level in the lesional epithelial cells after topical application of photosan gel. We found that photosan reached its peak level in cancerous lesions about 13.5 min after topical application of photosan gel. The cancerous lesions in hamsters were then treated with topical photosan-mediated PDT (fluence rate: 600 mW/cm2; light exposure dose 200 J/cm2) using the portable Lumacare 635 nm fiber-guided light device. Visual examination demonstrated that topical photosan-mediated PDT was an applicable treatment modality for DMBA-induced hamster buccal pouch cancerous lesions.

© (2011) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation

Yih-Chih Hsu ; Walter Hong-Shong Chang ; Junn-Liang Chang ; Kuang-Ting Liu ; Chun-Pin Chiang, et al.
"Topical photosan-mediated photodynamic therapy for DMBA-induced hamster buccal pouch early cancer lesions: an in vivo study", Proc. SPIE 7900, Biophotonics and Immune Responses VI, 790004 (February 10, 2011); doi:10.1117/12.879555; http://dx.doi.org/10.1117/12.879555


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