Full Content is available to subscribers

Subscribe/Learn More  >
Proceedings Article

Immunohistochemical analysis of immune response in breast cancer and melanoma patients after laser immunotherapy

[+] Author Affiliations
Robert E. Nordquist, Shelly L. Bishop

ImmunoPhotonics Inc. (USA) and Wound Healing of Oklahoma, Inc. (USA)

Halie Ferguson, Melville B. Vaughan, Jessnie Jose, Katherine Kastl, Long Nguyen, Wei R. Chen

Univ. of Central Oklahoma (USA)

Xiaosong Li

Univ. of Central Oklahoma (USA) and First Affiliated Hospital of Chinese PLA General Hospital (China) and Chinese PLA General Hospital (China)

Hong Liu

Univ. of Oklahoma (USA)

Proc. SPIE 7900, Biophotonics and Immune Responses VI, 790007 (February 23, 2011); doi:10.1117/12.874875
Text Size: A A A
From Conference Volume 7900

  • Biophotonics and Immune Responses VI
  • Wei R. Chen
  • San Francisco, California, USA | January 22, 2011

abstract

Laser immunotherapy (LIT) has shown great promise in pre-clinical studies and preliminary clinical trials. It could not only eradicate treated local tumors but also cause regression and elimination of untreated metastases at distant sites. Combining a selective photothermal therapy with an active immunological stimulation, LIT can induce systemic anti-tumor immune responses. Imiquimod (IMQ), a toll-like receptor agonist, was used for the treatment of late-stage melanoma patients and glycated chitosan (GC), a biological immunological modulator, was used for the treatment of late-stage breast cancer patients, in combination of irradiation of a near-infrared laser light. To observe the immunological changes before and after LIT treatment, the pathological tissues of melanoma and breast cancer patients were processed for immunohistochemical analysis. Our results show that LIT changed the expressions of several crucial T cell types. Specifically, we observed significant decreases of CD3+ T-cells and a significant increase of CD4+,CD8+, and CD68+ T-cells in the tumor samples after LIT treatment. While not conclusive, our study could shed light on one the possible mechanisms of anti-tumor immune responses induced by LIT. Further studies will be conducted to identify immunological biomarkers associated with LIT-induced clinical response.

© (2011) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation

Robert E. Nordquist ; Shelly L. Bishop ; Halie Ferguson ; Melville B. Vaughan ; Jessnie Jose, et al.
"Immunohistochemical analysis of immune response in breast cancer and melanoma patients after laser immunotherapy", Proc. SPIE 7900, Biophotonics and Immune Responses VI, 790007 (February 23, 2011); doi:10.1117/12.874875; http://dx.doi.org/10.1117/12.874875


Access This Proceeding
Sign in or Create a personal account to Buy this proceeding ($15 for members, $18 for non-members).

Figures

Tables

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

Advertisement
  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Proceeding
Sign in or Create a personal account to Buy this proceeding ($15 for members, $18 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.