Molecular mechanism of PDT-induced apoptotic cells stimulation NO production in macrophages

Sheng Song; Fei-fan Zhou; Si-hua Yang; Wei R. Chen

doi:10.1117/12.874324

10 February 2011 Molecular mechanism of PDT-induced apoptotic cells stimulation NO production in macrophages

Sheng Song, Fei-fan Zhou, Si-hua Yang, Wei R. Chen

Proceedings Volume 7900, Biophotonics and Immune Responses VI; 790008 (2011) https://doi.org/10.1117/12.874324
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

It is well known that apoptotic cells (AC) participate in immune response. The immune response induced by AC, either immunostimulatory or immunosuppressive, have been extensively studied. However, the molecular mechanisms of the immunostimulatory effects induced by PDT-treated AC remain unclear. Nitric oxide (NO) is an important signal transduction molecule and has been implicated in a variety of functions. It has also been found to play an important role not only as a cytotoxic effector but an immune regulatory mediator. In this study, we demonstrate that the PDT-induced apoptotic tumor cells stimulate the production of NO in macrophages by up-regulating expression of inducible nitric oxide synthase (iNOS). In addition, we show that AC, through toll-like receptors (TLRs), can activate myeloid differentiation factor-88 (MyD88), indicating that AC serves as an intercellular signal to induce iNOS expression in immune cells after PDT treatment. This study provided more details for understanding the molecular mechanism of the immune response induced by PDT-treated AC.

Citation Download Citation

Sheng Song, Fei-fan Zhou, Si-hua Yang, and Wei R. Chen "Molecular mechanism of PDT-induced apoptotic cells stimulation NO production in macrophages", Proc. SPIE 7900, Biophotonics and Immune Responses VI, 790008 (10 February 2011); https://doi.org/10.1117/12.874324

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KEYWORDS

NOx

Photodynamic therapy

Tumors

Cell death

Indium oxide

Luminescence

Molecular mechanisms

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