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Proceedings Article

Magnetic resonance-guided focused ultrasound surgery for treatment of painful osseous metastases

[+] Author Affiliations
Mark Hurwitz

Dana-Farber/Brigham and Women's Cancer Ctr., Harvard Medical School (USA)

Ronit Machtinger, Fiona Fennessy

Brigham and Women's Hospital, Harvard Medical School (USA)

Proc. SPIE 7901, Energy-based Treatment of Tissue and Assessment VI, 79010M (February 22, 2011); doi:10.1117/12.876434
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From Conference Volume 7901

  • Energy-based Treatment of Tissue and Assessment VI
  • Thomas P. Ryan
  • San Francisco, California, USA | January 22, 2011

abstract

Magnetic resonance guided focused ultrasound surgery (MRgFUS) is an emerging technology that can non-invasively heat and ablate targeted tissue utilizing ultrasound energy. Use of MR imaging for treatment guidance provides several key advantages over more widely used ultrasound guidance for focused ultrasound ablation. MR allows for precise targeting, detailed beam path visualization, real time non-invasive temperature measurement, and treatment feedback to ensure therapeutic goals are achieved. In the realm of oncology, management of painful bone metastases is a common and daunting clinical problem. The Insightec ExAblate System has been shown in phase I/II trials for treatment of bone metastases to have an excellent safety profile and high rates of pain response. An international multi-center phase III trial for patients with painful bone metastases or multiple myeloma who are not candidates for radiation therapy is currently open. Patients are randomized 3:1 to MRgFUS or sham treatment with crossover to study treatment allowed for sham failures. The primary study endpoint is assessment of pain control over 3 months following treatment. In addition safety, quality of life, cost effectiveness analysis, and patient perceived clinical benefit are also being assessed. Details of the MRgFUS system, technical and clinical therapeutic parameters, use of real time non-invasive MR thermometry, and examples of patient treatments with use of MRgFUS to treat bone metastases will be discussed. New directions in use of MRgFUS including an update on development of a new mobile applicator and integration of MRgFUS in multimodality oncologic care will also be presented.

© (2011) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation

Mark Hurwitz ; Ronit Machtinger and Fiona Fennessy
"Magnetic resonance-guided focused ultrasound surgery for treatment of painful osseous metastases", Proc. SPIE 7901, Energy-based Treatment of Tissue and Assessment VI, 79010M (February 22, 2011); doi:10.1117/12.876434; http://dx.doi.org/10.1117/12.876434


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