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Proceedings Article

Dual thermal ablation modality of solid tumors in a mouse model

[+] Author Affiliations
Gal Shafirstein, Klressa Barnes, Leah Hennings, Jessica Webber, Eduardo G. Moros, Beata Przybyla, Robert J. Griffin

Univ. of Arkansas for Medical Sciences (USA)

Proc. SPIE 7901, Energy-based Treatment of Tissue and Assessment VI, 79010Z (February 23, 2011); doi:10.1117/12.876427
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From Conference Volume 7901

  • Energy-based Treatment of Tissue and Assessment VI
  • Thomas P. Ryan
  • San Francisco, California, USA | January 22, 2011

abstract

Purpose: Develop a new combination therapy consisting of cryoablation and conductive high-temperature ablation for enhanced thermal ablation of solid tumors. Methods: We have constructed an invasive probe that can be used for consecutive cryoablation and hightemperature ablation (C/HTA), with a single insertion. The C/HTA probe was tested, in Balb/c mice bearing solid 4T1 tumors, in comparison to cryoablation and high temperature ablation, only. Three days after ablation, the diameter of the ablated zone was evaluated with pathological examination. Results: The C/HTA device can be used to induce larger ablation zones, in comparison to high temperature or cryoablation alone, and at lower thermal doses and temperatures than either modality alone. Conclusions: The relatively high thermal conductivity of ice, in comparison to water and native tissue, enables rapid heating of the ice-ball that result in improved conductive high temperature ablation. The new dual thermal modality improves ablation outcomes at lower thermal doses in comparison to a single ablation modality.

© (2011) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation

Gal Shafirstein ; Klressa Barnes ; Leah Hennings ; Jessica Webber ; Eduardo G. Moros, et al.
"Dual thermal ablation modality of solid tumors in a mouse model", Proc. SPIE 7901, Energy-based Treatment of Tissue and Assessment VI, 79010Z (February 23, 2011); doi:10.1117/12.876427; http://dx.doi.org/10.1117/12.876427


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